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MIV 150

CAS No. 231957-54-3

MIV 150 ( PC-815;MIV150 )

Catalog No. M13656 CAS No. 231957-54-3

A high-affinity, allosteric HIV-1 and HIV-2 reverse transcriptase inhibitor (NNRTI) with EC50 of 1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MIV 150
  • Note
    Research use only, not for human use.
  • Brief Description
    A high-affinity, allosteric HIV-1 and HIV-2 reverse transcriptase inhibitor (NNRTI) with EC50 of 1 nM.
  • Description
    A high-affinity, allosteric HIV-1 and HIV-2 reverse transcriptase inhibitor (NNRTI) with EC50 of 1 nM; possesses poor oral bioavailability, and demonstrates efficacy when formulated as a topical microbicide (PC-815: Carrageenan gel formulation).HIV Infection Phase 1 Clinical
  • Synonyms
    PC-815;MIV150
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    231957-54-3
  • Formula Weight
    368.40
  • Molecular Formula
    C19H17FN4O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N[C@@H]1[C@H](C2=C(F)C=CC(C(CC)=O)=C2O)C1)NC3=NC=C(C#N)C=C3
  • Chemical Name
    N-(5-Cyano-2-pyridinyl)-N'-[(1S,2S)-2-[6-fluoro-2-hydroxy-3-(1-oxopropyl)phenyl]cyclopropyl]urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Geitmann M, et al. J Med Chem. 2006 Apr 20;49(8):2367-74.
2. Fernández-Romero JA, et al. Sex Transm Dis. 2007 Jan;34(1):9-14.
3. Singer R, et al. Sci Transl Med. 2012 Sep 5;4(150):150ra123.
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